Reorganization of the structural elements of the venous wall in oncogenic pathology

The objective: an identification of changes and reorganization structural elements the venous wall, their correlation with cancer processes in organism; establishment relationship between wall vessels thrombosis, following complications; determination necessity preventive measures to avoid complications. Materials methods. Histological, submicroscopic polarization data research veins hind limbs 12 sexually mature nonlinear male rats weighing 170–180 g on 30th day chronic neoplastic intoxication were analyzed. A retrospective analysis autopsy protocols patients (n=54), largest incidences – pulmonary embolism, during 2014-2018 Ternopil Regional Clinical Oncology Center was performed. average age women who died 61.93±1.51 years 62.44±2.61 for men.Results. As a result morphological examination experimental revealed mainly endothelial cells desquamation, as well platelet aggregation that can be one links pathogenesis thrombosis.According protocols, proportion embolism higher among (61.1 %) than men (38.9 %). structure oncopathology this group patients: bronchial lung (18.5 %); neoplasms uterine body (22.2 rectum (13.0 %), colon (7.4 rectosigmoid junction (5.6 bladder (9.3 gastric ovarian prostate thyroid (1.8 pancreatic In all cases phlebothrombosis deep leg thigh impaired blood flow caused by occlusion clots various manifestations organization revealed. five cases, fresh red found, which closely connected intima fibrin threads, other freely located lumen vein, swelling layers fibrous diffuse neutrophil infiltration found. remaining 44 vein detected already organized thrombi signs fibrosis, recanalization, revascularization.Conclusions. study morphology rat limb shape, function endotheliocytes, desquamation three ligation. presence formation thrombosis number thromboembolic complications emphasizes prevent patients.